Bioreaction Engineering

Subject description

  • modelling and analysis of biochemical engineering processes;
  • bioprocess kinetics: growth of microorganisms (Monod, growth on multiple substrates, inhibition, …), enzyme kinetics (Michaelis- Menten,…);
  • mass and energy balances: reaction and separation bioprocesses; enthalpy changes;
  • basic fluid dynamics: ideal and nonideal flow models, 3D velocity profile prediction of single and multiphase flow;
  • numerical analysis basics: ordinary differential equations (exact solutions, Euler's method, Euler trapeze method, Runge-Kutta methods, systems of ordinary differential equations, numerical integration; numerical solution of partial differential equations: explicit and implicit finite difference methods, analytical and numerical solution of Laplace’s equation;
  • conservation equations;
  • development of 2D and 3D mathematical models considering velocity profile and reaction diffusion dynamics terms;
  • applications of computational tools (Mathematica, COMSOL, Matlab);
  • bioprocess modelling of selected cases (modelling and experimental studies on enzyme-catalyzed reaction in a microreactor; biotransformation in a microreactor with surface immobilized enzymes or cells; batch and continuous steroid biotransformation process with immobilized biomass; modelling of a pilot wastewater treatment plant,..).

The subject is taught in programs

Objectives and competences

To develop skills for independent research work in the field of bio-processes, their theoretical description, design and optimization, with emphasis on environmentally acceptable biotechnologies

Teaching and learning methods

Lectures, seminars, project workshops. Individual study with consultation.

Expected study results

Ability for solving various engineering tasks and problems of bioprocess technologies.

Basic sources and literature

  • I. Plazl, M. Lakner, Uvod v modeliranje procesov, Založba FKKT, Univerza v Ljubljani, Ljubljana, 2004, 230 str.
  • J. Nielsen, J.Villadsen, Bioreaction Engineering Principles, Plenum Press, New York, 1994.
  • M-L.Shuler, F. Kargi, Bioprocess Engineering: Basic Concepts, Prentice-Hall, Upper Saddle River, NJ, 2002.

Tekoča znanstvena periodika / Current scientific periodicals.

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