Biosciences and surgery

Subject description

  1. An overview of the most common surgical treatments for ear disease and the lateral and anterior skull-base
  2. Review of the role of foreign and the body's own materials and substances in otorhinolaryngology
  3. Composition, preparation and use of platelet-rich plasma and extracellular vesicles in medicine.
  4. Review of the use of mitomycin in the treatment of external auditory canal narrowing
  5. Review of the use of implants in otorhinolaryngology
    1. cochlear implant
    2. bone-anchored hearing aid
  6. Criteria for assessing treatment outcome
    1. objective: surface measurement, clinical scores etc.
    2. subjective: health-related quality of life questionnaires

7. An overview  of the most common biocompatible materials used in orthopedic surgery j

8. Review of phenomena the surface of uncemented  hip endoprostheses

(surface wetting and roughness and cell response)

9. Review of osteointegration proceses of multifuncion coatings on nanostructructured  surface of metalliic materials with the aim to  improve osteointegration between implant and bone.


The subject is taught in programs

Objectives and competences

Learns about the use of biochemical, bioactive preparations, mechanical and electromagnetic implants and preparations from human body fluids in improving the results of classical surgical techniques in the field of:

  • Chronic temporal bone inflammation
  • Treatment of chronic otitis media
  • Hearing rehabilition in deaf people
  • Closure of surgical approaches to the lateral and anterior skull-base.

      Student  get the  basic knowledge and understanding in the field of bio engineering materials and tissues for the applications in orthopredic surgery and rechabilitation

Teaching and learning methods

Lectures, discussion workshops of presented seminars

Demonstration of already introduced biomedical methods in surgery

Presentation of existing literature

Familiarization with ongoing research

Guidelines for further development of the field

Expected study results

Knowledge and understanding:

• Interdisciplinary scientific approaches in surgical treatment

• The importance of improving classical surgical techniques

• Methods of tracking surgical results

• Identification of failures of classical surgical techniques

• Finding areas and ways to improve the treatment outcome

–Methods  of following surgical results  on the  base of the investigations of prematurely failed hip and knee endoprosthesis   

Finding new biomaterials combiinations  with the aim to improve lifetime of implants

Basic sources and literature

  • Battelino S. Avdiometrija, vestibulometrija in avdiološka elektroakustika v vsakdanji praksi: učbenik za tečajnike avdiometrije in vestibulometrije, avdiološke elektroakustike, logopede, študente splošne in dentalne medicine, specializante otorinolaringologije, klinične logopedije in nevrologije ter specializante medicine dela, prometa in športa [Internet]. Katedra za otorinolaringologijo Medicinske fakultete; 2017.
  • Battelino S, Hocevar-Boltezar I, Zargi M. Intraoperative use of mitomycin C in fibrous atresia of the external auditory canal. Ear Nose Throat J. 2005 Dec;84(12):776-9. PMID: 16408556.
  • Vozel D, Steiner N, Božanić Urbančič N, Mladenov D, Battelino S. Slovenian Cross-Cultural Adaptation and Validation of Health-Related Quality of Life Measures for Chronic Otitis Media (COMQ-12), Vertigo (DHI, NVI) and TINNITUS (THI). Zdr Varst. 2020 Jun 25;59(3):120-127. doi: 10.2478/sjph-2020-0016. PMID: 32952712; PMCID: PMC7478096.
  • Vozel D, Božič D, Jeran M, Jan Z, Pajnič M, Pađen L, idr. Treatment with platelet- and extracellular vesicle-rich plasma in otorhinolaryngology-a review and future perspectives. V: Advances in Biomembranes and Lipid Self-Assembly [Internet]. Academic Press; 2020. Dostopno na:
  • Vozel D, Battelino S. Preparation of platelet- and extracellular vesicle-rich gel and its role in the management of cerebrospinal fluid leak in anterior and lateral skull-base surgery. V: Zbornik recenziranih prispevkov [Internet]. Ljubljana: Zdravstvena fakulteta; 2020. str. 47–58. Dostopno na:,
  • Vozel D, Božič D, Jeran M, Jan Z, Pajnič M, Pađen L, idr. The role of platelet-and extracellular vesicle-rich plasma in the treatment of temporal bone cavity inflammation : a randomized controlled trial. V: Zbornik recenziranih prispevkov [Internet]. Ljubljana: Zdravstvena fakulteta; 2020. str. 41–52. Dostopno na:
  • DOLINAR, Drago. Novosti v endoprotetiki kolčnega in kolenskega sklepa. V: PAVLOVČIČ, Vinko (ur.). Novosti v ortopediji. Ljubljana: Ortopedska klinika, Klinični center. 2008, str. 99-105. [COBISS.SI-ID 24231129]
  • LOTRIČ-FURLAN, Stanka, DOLINAR, Drago, KOŠAK, Robert, KOTAR, Tadeja. Kirurške okužbe sklepov in kosti = Surgical infections of joints and bones. V: BEOVIĆ, Bojana (ur.), STRLE, Franc (ur.), ČIŽMAN, Milan (ur.). Zbornik predavanj : [okužbe, ki potrebujejo kirurško zdravljenje]. Ljubljana: Sekcija za kemoterapijo SZD: Klinični center, Klinika za infekcijske bolezni in vročinska stanja: Univerza v Ljubljani, Medicinska fakulteta, Katedra za infekcijske bolezni in epidemiologijo. 2007, str. 185-201. [COBISS.SI-ID 23114201]
  • Park J. B., & Bronzino J. D.(eds.) (2003) "Biomaterials Principles and Applications", CRC

           Press  Beer F., Johnston E., & Dewolf J. (2001) "Mechanics of Materials" 3rd Edition

           McGraw- Hill

         Budinski K. G., & Budinski M. K.(2001) Edition, "Engineering Materials Properties and Selection" 7th Edition, Prentice Hall.

  • Benham P. P., Crawford R. J., & Armstrong C. G.(1996) "Mechanics of Engineering

Materials" 2nd Edition, Addison Wesley Longman LTD

  • Bronzino J. D. (Ed) (1999), "The Biomedical Engineering Handbook", 2nd Edition

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