Biosciences and surgery

Subject description

An overview of the most common surgical treatments for ear disease and the lateral and anterior skull-base
Review of the role of foreign and the body's own materials and substances in otorhinolaryngology
Composition, preparation and use of platelet-rich plasma and extracellular vesicles in medicine.
Review of the use of mitomycin in the treatment of external auditory canal narrowing
Review of the use of implants in otorhinolaryngology
1. cochlear implant
2. bone-anchored hearing aid
Criteria for assessing treatment outcome
1. objective: surface measurement, clinical scores etc.
2. subjective: health-related quality of life questionnaires

7. An overview of the most common biocompatible materials used in orthopedic surgery j

8. Review of phenomena the surface of uncemented hip endoprostheses

(surface wetting and roughness and cell response)

9. Review of osteointegration proceses of multifuncion coatings on nanostructructured surface of metalliic materials with the aim to improve osteointegration between implant and bone.

The subject is taught in programs

Objectives and competences

Learns about the use of biochemical, bioactive preparations, mechanical and electromagnetic implants and preparations from human body fluids in improving the results of classical surgical techniques in the field of:

Chronic temporal bone inflammation
Treatment of chronic otitis media
Hearing rehabilition in deaf people
Closure of surgical approaches to the lateral and anterior skull-base.

Student get the basic knowledge and understanding in the field of bio engineering materials and tissues for the applications in orthopredic surgery and rechabilitation

Teaching and learning methods

Lectures, discussion workshops of presented seminars

Demonstration of already introduced biomedical methods in surgery

Presentation of existing literature

Familiarization with ongoing research

Guidelines for further development of the field

Expected study results

Knowledge and understanding:

• Interdisciplinary scientific approaches in surgical treatment

• The importance of improving classical surgical techniques

• Methods of tracking surgical results

• Identification of failures of classical surgical techniques

• Finding areas and ways to improve the treatment outcome

–Methods of following surgical results on the base of the investigations of prematurely failed hip and knee endoprosthesis

Finding new biomaterials combiinations with the aim to improve lifetime of implants

Basic sources and literature

Battelino S. Avdiometrija, vestibulometrija in avdiološka elektroakustika v vsakdanji praksi: učbenik za tečajnike avdiometrije in vestibulometrije, avdiološke elektroakustike, logopede, študente splošne in dentalne medicine, specializante otorinolaringologije, klinične logopedije in nevrologije ter specializante medicine dela, prometa in športa [Internet]. Katedra za otorinolaringologijo Medicinske fakultete; 2017.

Battelino S, Hocevar-Boltezar I, Zargi M. Intraoperative use of mitomycin C in fibrous atresia of the external auditory canal. Ear Nose Throat J. 2005 Dec;84(12):776-9. PMID: 16408556.

Vozel D, Steiner N, Božanić Urbančič N, Mladenov D, Battelino S. Slovenian Cross-Cultural Adaptation and Validation of Health-Related Quality of Life Measures for Chronic Otitis Media (COMQ-12), Vertigo (DHI, NVI) and TINNITUS (THI). Zdr Varst. 2020 Jun 25;59(3):120-127. doi: 10.2478/sjph-2020-0016. PMID: 32952712; PMCID: PMC7478096.

Vozel D, Božič D, Jeran M, Jan Z, Pajnič M, Pađen L, idr. Treatment with platelet- and extracellular vesicle-rich plasma in otorhinolaryngology-a review and future perspectives. V: Advances in Biomembranes and Lipid Self-Assembly [Internet]. Academic Press; 2020. Dostopno na: http://www.sciencedirect.com/science/article/pii/S2451963420300224

Vozel D, Battelino S. Preparation of platelet- and extracellular vesicle-rich gel and its role in the management of cerebrospinal fluid leak in anterior and lateral skull-base surgery. V: Zbornik recenziranih prispevkov [Internet]. Ljubljana: Zdravstvena fakulteta; 2020. str. 47–58. Dostopno na: http://www2.zf.uni-lj.si/images/stories/datoteke/Zalozba/Sokratska_2019.pdf, https://repozitorij.uni-lj.si/IzpisGradiva.php?id=113167&lang=slv

Vozel D, Božič D, Jeran M, Jan Z, Pajnič M, Pađen L, idr. The role of platelet-and extracellular vesicle-rich plasma in the treatment of temporal bone cavity inflammation : a randomized controlled trial. V: Zbornik recenziranih prispevkov [Internet]. Ljubljana: Zdravstvena fakulteta; 2020. str. 41–52. Dostopno na: https://repozitorij.uni-lj.si/IzpisGradiva.php?id=113109&lang=slv

DOLINAR, Drago. Novosti v endoprotetiki kolčnega in kolenskega sklepa. V: PAVLOVČIČ, Vinko (ur.). Novosti v ortopediji. Ljubljana: Ortopedska klinika, Klinični center. 2008, str. 99-105. [COBISS.SI-ID 24231129]

LOTRIČ-FURLAN, Stanka, DOLINAR, Drago, KOŠAK, Robert, KOTAR, Tadeja. Kirurške okužbe sklepov in kosti = Surgical infections of joints and bones. V: BEOVIĆ, Bojana (ur.), STRLE, Franc (ur.), ČIŽMAN, Milan (ur.). Zbornik predavanj : [okužbe, ki potrebujejo kirurško zdravljenje]. Ljubljana: Sekcija za kemoterapijo SZD: Klinični center, Klinika za infekcijske bolezni in vročinska stanja: Univerza v Ljubljani, Medicinska fakulteta, Katedra za infekcijske bolezni in epidemiologijo. 2007, str. 185-201. [COBISS.SI-ID 23114201]

Park J. B., & Bronzino J. D.(eds.) (2003) "Biomaterials Principles and Applications", CRC

Press Beer F., Johnston E., & Dewolf J. (2001) "Mechanics of Materials" 3rd Edition

McGraw- Hill

Budinski K. G., & Budinski M. K.(2001) Edition, "Engineering Materials Properties and Selection" 7th Edition, Prentice Hall.

Benham P. P., Crawford R. J., & Armstrong C. G.(1996) "Mechanics of Engineering

Materials" 2nd Edition, Addison Wesley Longman LTD

Bronzino J. D. (Ed) (1999), "The Biomedical Engineering Handbook", 2nd Edition